ANTI-HYPERLIPIDEMIC ACTIVITY OF ALCOHOLIC AND METHONOLIC EXTRACTS OF CROTOLARIA JUNCEA IN TRITON-WR 1339 INDUCED HYPERLIPIDEMIA 

ABSTRACT

Hyperlipidemia is the greatest risk factor of coronary heart disease. Currently available hypolipidemic drugs have been associated with number of side effects. Herbal treatment for hyperlipidemia has no side effects and is relatively cheap and locally available. Literature claims that Saponins are able to reduce hyperlipidemia. Based on high saponin content in herbal plants, Crotolaria juncea (CJ) was selected and the present study focus on the antihyperlipidemic activity of alcoholic and methanol extract of leaves of CJ against Triton induced hyperlipidemia in mice. CJ was administered at a dose of 100 and 200mg/kg (p.o) to Triton induced hyperlipidemic mice. Atorvastatin was used as reference standard. trx straps for sale The statistical analyses were carried out using one way ANOVA followed by bonferroni test using computer based fitting program (Prism, Graph pad.). CJ shows a significant decrease in the levels of serum total cholesterol, triglyceride, LDL, VLDL and significant increase in the level of serum HDL at the dose of 100 and 200mg/kg (p.o) against Triton induced hyperlipidemia in mice. Methanol and alcoholic extracts of CJ showed significant anti-hyperlipidemic effect and this study provides the scientific proof for their traditional claims. Therefore it effectively suppressed the Triton induced hyperlipidemia in mice, suggesting the potential protective role in Coronary heart disease.

Key Words: Crotolaria juncea, Hyperlipidemia, Triglycerides, Saponin, Lipoproteins, Triton-WR 1339, Atorvastatin.